Thrombospondin-4 is required for stretch-mediated contractility augmentation in cardiac muscle.

Integrative Physiology Thrombospondin-4 Is Required for Stretch-Mediated Contractility Augmentation in Cardiac Muscle Short Communication

Effects of Physiologic Mechanical Stimulation on Embryonic Chick Cardiomyocytes Using a Microfluidic Cardiac Cell Culture Model

Hemodynamic mechanical cues play a critical role in the early development and functional maturation of cardiomyocytes (CM). Therefore, tissue engineering approaches that incorporate immature CM into functional cardiac tissues capable of recovering or replacing damaged cardiac muscle require physiologically relevant environments to provide the appropriate mechanical cues. The goal of this work i...

Comparison of ultrasound along with muscle stretch with ultrasound and muscle stretch along in the treatment of myofascial trigger points

this study was a clinical trial performed using consecutive method of samplind for 3.5 years in the physiotherapy clinic of Rafsanjan university of medocal sciences.the purpose of this research was to evaluate the effect of the ultrasound along with muscle stretch with ultrasound and muscle stretch along in the treatment of the myofascial trigger points(MTPs).one haundred and twenty patients wh...

Stretch-induced increase in cardiac contractility is independent of myocyte Ca2+ while block of stretch channels by streptomycin improves contractility after ischemic stunning

Stretching the cardiac left ventricle (LV) enhances contractility but its effect on myoplasmic [Ca(2+)] is controversial. We measured LV pressure (LVP) and [Ca(2+)] as a function of intra-LV stretch in guinea pig intact hearts before and after 15 min global stunning ± perfusion with streptomycin (STM), a stretch-activated channel blocker. LV wall [Ca(2+)] was measured by indo-1 fluorescence and...

Increased coronary perfusion augments cardiac contractility in the rat through stretch-activated ion channels.

The role of stretch-activated ion channels (SACs) in coronary perfusion-induced increase in cardiac contractility was investigated in isolated isometrically contracting perfused papillary muscles from Wistar rats. A brief increase in perfusion pressure (3-4 s, perfusion pulse, n = 7), 10 repetitive perfusion pulses (n = 4), or a sustained increase in perfusion pressure (150-200 s, perfusion ste...